Tirzepatide Side Effects
Medically reviewed by Dr. Jonathan Snipes, MD
Reviewed for clinical accuracy · Last reviewed July 22, 2026 · Review policy
Quick answer
The most common Tirzepatide side effects are nausea, diarrhea, vomiting, constipation and decreased appetite, indigestion, and are usually mild and dose-related. Serious effects are less common; the full breakdown and cautions are below.
| Effect | Frequency |
|---|---|
| NauseaDose-dependent, usually early | Common |
| Diarrhea, vomiting, constipation | Common |
| Decreased appetite, indigestion | Common |
| Gallbladder problems | Less common |
| Acute pancreatitis | Rare |
| Thyroid C-cell tumorsBoxed warning from rodent data; contraindicated with MTC history or MEN 2 | Rare |
Tirzepatide's tolerability profile closely mirrors semaglutide: predominantly gastrointestinal effects that are worst during dose escalation and tend to settle over time. Serious events (gallbladder disease, rare pancreatitis) are uncommon, and it carries the same boxed warning for thyroid C-cell tumors observed in rodents, with the same contraindication for people who have a personal or family history of medullary thyroid carcinoma or MEN 2.
Frequently asked questions
What are the most common Tirzepatide side effects?+
The most common Tirzepatide side effects are nausea, diarrhea, vomiting, constipation and decreased appetite, indigestion. See the full frequency table above for less common and rare effects.
Is Tirzepatide safe?+
Tirzepatide is FDA-approved and, used under medical supervision, is generally tolerated, but it is not risk-free: it has side effects and specific contraindications. Discuss your history with a clinician.